(313) 577-6739 (fax)
AddressInstitute of Environmental Health Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201
Office Phone(313) 577-5598
Dr. Runge-Morris' primary research program is dedicated to understanding the molecular mechanisms that regulate the expression of the sulfotransferase multigene family. The cytosolic sulfotransferase conjugating enzymes are vitally important to drug metabolism. These enzymes detoxify many xenobiotic and endogenous substrates by forming more polar products that are amenable to excretion and elimination from the body. However, if the sulfated conjugate is unstable, loss of the labile sulfate group can create highly reactive electrophiles that may damage cellular macromolecules such as DNA. Many of the sulfotransferases in liver and other tissues, have been implicated in the bioactivation of environmental carcinogens. In addition to these important biological functions, the sulfotransferases also modulate intra-tissue hormone activity. Because sulfated hormones generally are receptor inactive, induction of sulfotransferase gene expression can reduce the levels of bioactive steroid hormone that are available to bind to cellular receptors. In human pathology, the sulfotransferases are in a prime position to influence the development and progression of hormone responsive tumors such as breast and prostate cancer.
Dr. Runge-Morris' laboratory is currently investigating the key transcription factor and cis-acting response elements that are responsible for regulating changes in sulfotransferase gene transcription. Recently, her research group reported that glucocorticoid hormones and xenobiotics such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and phenobarbital produce differential effects on the mRNA expression of individual sulfotransferase isoforms in rat liver and in primary cultured rat hepatocytes. As an overall research objective, Dr. Runge-Morris maintains that identifying and characterizing the factors that control gene expression during critical periods of development and aging will lead to new insights on disease mechanisms in humans.
DepartmentInstitute of Environmental Health Sciences
To view Dr. Runge-Morris' most recent publications, please visit PubMed at https://pubmed.ncbi.nlm.nih.gov/?term=melissa%20runge-morris