(313) 972-8025 (fax)
AddressIntegrative Biosciences Center (IBio); 6135 Woodward Ave Detroit, MI
Mechanisms of Adult Onset and Transgenerational Disease due to Environmental Contaminants
The Baker Lab is focused on multidisciplinary, translational research that bridges human, animal and environmental health. Specifically, we aim to inform the connection of toxicant-induced phenotypic and functional abnormalities from multiple generations with changes in genome function and epigenetic regulation, as well as to identify critical windows for biomarkers of effect and interplay among pathways mediating toxic endpoints. Thus, our research goal is to provide critical insights into transgenerational, environmentally-induced disease. In addition to human health, results from this work are being applied to wild fish populations that are experiencing population-level consequences of reduced reproductive capacity secondary to environmental toxicants in our waterways. Wild fish not only serve important ecological roles and serve as indicators of aquatic ecosystem health, but are also an increasingly important protein source for people worldwide.
One project of my lab is directed at the transcriptomic and epigenetic mechanisms of adult-onset and transgenerational disease in zebrafish resulting from exposure to TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin), a known EDC of concern in humans. We also currently have funding to investigate the occurrence and effects of endocrine disruption due to environmental contaminants in Detroit waterbodies, exogenous factors linked to the development of childhood leukemia, occurrence of microplastics in drinking water and the consequential impact on human health, lead-induced transgenerational neurobehavioral toxicity and transcriptomic changes, and the use of novel assay systems to evaluate health effects of volatile organic chemicals.
Please visit our WATER lab website at: bakerwaterlab.com
DepartmentInstitute of Environmental Health Sciences and Department of Pharmacology
Meyer DN, Baker BB, and Baker TR. 2018. Ancestral TCDD exposure induces multigenerational histologic and transcriptomic alterations in gonads of male zebrafish. Toxicological Sciences. 164(2):603-612.
Gawdzik JC, Yue M, Martin NR, Elemans LM, Lanham K, Heideman W, Rezendes R, Baker TR, Taylor MR and Plavicki JS. 2018. sox9b is required in cardiomyocytes for cardiac morphogenesis and function. Scientific Reports, 8:13906
Plavicki J, Baker TR, Burns F, Xiong K, Gooding A, Hofsteen P, Peterson RE and Heideman W. 2015. Construction and characterization of a sox9b transgenic reporter line. International Journal of Developmental Biology. 58: 693-99.
Baker BB, Yee JS, Meyer DN, Yang D and Baker TR. 2016. Histological and Transcriptomic Changes in Male Zebrafish Testes Due to Early Life Exposure to Low Level 2,3,7,8-Tetrachlorodibenzo-p-Dioxin. Zebrafish. 13(5):413-23.
Baker TR, Peterson RE and Heideman W. 2014. Using zebrafish as a model system for studying the transgenerational effects of dioxin. Toxicological Sciences. 138 (1):403-11.
Baker TR, King-Heiden TC, Peterson RE and Heideman W. 2014. Dioxin Induction of Transgenerational Inheritance of Disease in Zebrafish. Molecular and Cellular Endocrinology. 398(1-2):36-41.
Baker TR, Peterson RE and Heideman W. 2013. Early dioxin exposure causes toxic effects in adult zebrafish. Toxicological Sciences. 135(1):241-50.
Baker TR, Baker BB, Johnson SM, and Sladky KK. 2013. Comparative analgesic efficacy of morphine and butorphanol in koi (Cyprinus carpio) undergoing gonadectomy. Journal of the American Veterinary Medical Association. 243(6):882-90.
Baker TR, Doucette GJ, Powell CL, Boyer GL, and Plumley FG. 2003. GTX(4) imposters: characterization of fluorescent compounds synthesized by Pseudomonas stutzeri SF/PS and Pseudomonas/Alteromonas PTB-1, symbionts of saxitoxin-producing Alexandrium spp. Toxicon. 41(3):339-47.